I think the humor helps a lot. Plus, very important, even when I myself am really frustrated and down, I never let them see it. Because I feel it’s my job to sort of keep things upbeat, et cetera.  But it is very, very difficult because failure is our constant companion.  I often repeat to them something that — not my mentor, but a senior scientist at the NIH — said to me once. We were having lunch together. I was despondent, despondent because nothing had worked. I had been there a year. And this guy said to me, “Look,” he said, “do you know the difference, Bob, between an average scientist and a world class scientist?” I said no. He said, “Here’s what it is.” He said, “For the average scientist, maybe one percent of their experiments work. But for the world class guy, the world beater, it could be as high as one-and-a-half or two percent.” And then that really stuck with me because it’s really true. It’s that little difference. But still 98 percent doesn’t work, even if you’re winning the Nobel Prize.